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Microdosing For Depression Appears To Work About As Well As Drinking Coffee

Slashdot.org - Sat, 01/31/2026 - 08:00
An anonymous reader quotes a report from Wired: About a decade ago, many media outlets -- including WIRED -- zeroed in on a weird trend at the intersection of mental health, drug science, and Silicon Valley biohacking: microdosing, or the practice of taking a small amount of a psychedelic drug seeking not full-blown hallucinatory revels but gentler, more stable effects. Typically using psilocybin mushrooms or LSD, the archetypal microdoser sought less melting walls and open-eye kaleidoscopic visuals than boosts in mood and energy, like a gentle spring breeze blowing through the mind. Anecdotal reports pitched microdosing as a kind of psychedelic Swiss Army knife, providing everything from increased focus to a spiked libido and (perhaps most promisingly) lowered reported levels of depression. It was a miracle for many. Others remained wary. Could 5 percent of a dose of acid really do all that? A new, wide-ranging study by an Australian biopharma company suggests that microdosing's benefits may indeed be drastically overstated -- at least when it comes to addressing symptoms of clinical depression. A Phase 2B trial of 89 adult patients conducted by Melbourne-based MindBio Therapeutics, investigating the effects of microdosing LSD in the treatment of major depressive disorder, found that the psychedelic was actually outperformed by a placebo. Across an eight-week period, symptoms were gauged using the Montgomery-Asberg Depression Rating Scale (MADRS), a widely recognized tool for the clinical evaluation of depression. The study has not yet been published. But MindBio's CEO Justin Hanka recently released the top-line results on his LinkedIn, eager to show that his company was "in front of the curve in microdosing research." He called it "the most vigorous placebo controlled trial ever performed in microdosing." It found that patients dosed with a small amount of LSD (ranging from 4 to 20g, or micrograms, well below the threshold of a mind-blowing hallucinogenic dose) showed observable upticks in feelings of well-being, but worse MADRS scores, compared to patients given a placebo in the form of a caffeine pill. (Because patients in psychedelic trials typically expect some kind of mind-altering effect, studies are often blinded using so-called "active placebos," like caffeine or methylphenidate, which have their own observable psychoactive properties.) This means, essentially, that a medium-strength cup of coffee may prove more beneficial in treating major depressive disorder than a tiny dose of acid. Good news for habitual caffeine users, perhaps, but less so for researchers (and biopharma startups) counting on the efficacy of psychedelic microdosing. "It's probably a nail in the coffin of using microdosing to treat clinical depression," Hanka says. "It probably improves the way depressed people feel -- just not enough to be clinically significant or statistically meaningful."

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Author of Systemd Quits Microsoft To Prove Linux Can Be Trusted

Linux.Slashdot.org - Sat, 01/31/2026 - 05:00
Lennart Poettering has left Microsoft to co-found Amutable, a new Berlin-based company aiming to bring cryptographically verifiable integrity and deterministic trust guarantees to Linux systems. He said in a post on Mastodon that his "role in upstream maintenance for the Linux kernel will continue as it always has." Poettering will also continue to remain deeply involved in the systemd ecosystem. The Register reports: Linux celeb Lennart Poettering has left Microsoft and co-founded a new company, Amutable, with Chris Kuhl and Christian Brauner. Poettering is best known for systemd. After a lengthy stint at Red Hat, he joined Microsoft in 2022. Kuhl was a Microsoft employee until last year, and Brauner, who also joined Microsoft in 2022, left this month. [...] It is unclear why Poettering decided to leave Microsoft. We asked the company to comment but have not received a response. Other than the announcement of systemd 259 in December, Poettering's blog has been silent on the matter, aside from the announcement of Amutable this week. In its first post, the Amutable team wrote: "Over the coming months, we'll be pouring foundations for verification and building robust capabilities on top." It will be interesting to see what form this takes. In addition to Poettering, the lead developer of systemd, Amutable's team includes contributors and maintainers for projects such as Linux, Kubernetes, and containerd. Its members are also very familiar with the likes of Debian, Fedora, SUSE, and Ubuntu.

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Categories: Linux

Author of Systemd Quits Microsoft To Prove Linux Can Be Trusted

Slashdot.org - Sat, 01/31/2026 - 05:00
Lennart Poettering has left Microsoft to co-found Amutable, a new Berlin-based company aiming to bring cryptographically verifiable integrity and deterministic trust guarantees to Linux systems. He said in a post on Mastodon that his "role in upstream maintenance for the Linux kernel will continue as it always has." Poettering will also continue to remain deeply involved in the systemd ecosystem. The Register reports: Linux celeb Lennart Poettering has left Microsoft and co-founded a new company, Amutable, with Chris Kuhl and Christian Brauner. Poettering is best known for systemd. After a lengthy stint at Red Hat, he joined Microsoft in 2022. Kuhl was a Microsoft employee until last year, and Brauner, who also joined Microsoft in 2022, left this month. [...] It is unclear why Poettering decided to leave Microsoft. We asked the company to comment but have not received a response. Other than the announcement of systemd 259 in December, Poettering's blog has been silent on the matter, aside from the announcement of Amutable this week. In its first post, the Amutable team wrote: "Over the coming months, we'll be pouring foundations for verification and building robust capabilities on top." It will be interesting to see what form this takes. In addition to Poettering, the lead developer of systemd, Amutable's team includes contributors and maintainers for projects such as Linux, Kubernetes, and containerd. Its members are also very familiar with the likes of Debian, Fedora, SUSE, and Ubuntu.

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'Reverse Solar Panel' Generates Electricity at Night

Slashdot.org - Sat, 01/31/2026 - 02:00
Researchers at the University of New South Wales are developing a "reverse solar panel" that generates small amounts of electricity at night by harvesting infrared heat radiated from Earth. "In the past, scientists have demonstrated that a 'thermoradiative diode' can convert infrared radiation directly into electricity; when used to convert heat from Earth, they exploit the temperature difference between Earth and the night sky, generating a current directly from heat," notes ExtremeTech. "This approach completely eliminates the need for heat to generate steam, though the resulting capacity is fairly low." From the report: The researchers estimate they could generate only about a watt per square meter, which isn't much. One reason for the low output is that the Earth's atmosphere lessens the heat differential that drives the generative process; in space, though, that's not an issue. Now, researchers believe that the ability to generate power in the moments between direct sunlight could help power satellites. That could be especially true in deep space, where periods without sunlight can be longer, and sunlight is often weaker; in these situations, losing electricity to heat loss is unacceptable. Many satellites already use heat to generate electricity, though with a much more rarified "thermoelectric generator" that uses rare, expensive materials like plutonium to create heat. With thermoradiative diodes, the heat source can be the Sun-warmed body of the satellite itself.

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UK's First Rapid-Charging Battery Train Ready For Boarding

Slashdot.org - Fri, 01/30/2026 - 22:30
An anonymous reader quotes a report from the Guardian: The UK's first superfast-charging train running only on battery power will come into passenger service this weekend -- operating a five-mile return route in west London. Great Western Railway (GWR) will send the converted London Underground train out from 5.30am to cover the full Saturday timetable on the West Ealing to Greenford branch line, four stops and 12 minutes each way, and now carrying up to 273 passengers, should its celebrity stoke up the demand. The battery will recharge in just three and a half minutes back at West Ealing station between trips, using a 2,000kW charger connected to a few meters of rail that only becomes live when the train stops directly overhead. There are hopes within government and industry that this technology could one day replace diesel trains on routes that have proved difficult or expensive to electrify with overhead wires, as the decarbonization of rail continues. The train has proved itself capable of going more than 200 miles on a single charge -- last year setting a world record for the farthest travelled by a battery-electric train, smashing a German record set in 2021. The GWR train and the fast-charge technology has been trialled on the 2.5-mile line since early 2024, but has not yet carried paying passengers.

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Apple Reports Best-Ever Quarter For iPhone Sales

Slashdot.org - Fri, 01/30/2026 - 20:25
Apple posted its biggest quarter ever, with iPhone revenue hitting a record ~$85.3 billion and Services climbing 14% to ~$30 billion. Total revenue reached nearly $143.76 billion. "The demand for iPhone was simply staggering," CEO Tim Cook said on a conference call discussing the results. "This is the strongest iPhone lineup we've ever had and by far the most popular."

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Belkin's Wemo Smart Devices Will Go Offline On Saturday

Slashdot.org - Fri, 01/30/2026 - 19:45
Belkin is shutting down cloud support for most Wemo smart home devices on January 31, leaving only Thread-based models and devices already set up in Apple HomeKit functional. Everything else will lose remote access, voice assistant integrations, and future app updates. The Verge reports: The shut down was first announced in July and impacts most Wemo devices, ranging from smart plugs to a coffee maker, with the exception of a handful of Thread-based devices: the 3-way smart light switch (WLS0503), stage smart scene controller (WSC010), smart plug with Thread (WSP100), and smart video doorbell camera (WDC010). Wemo devices configured through Apple's HomeKit will also continue to work, but you have to set them up in HomeKit before January 31st if you want to use that option. Other affected devices will only work manually after Saturday. If your Wemo device is still under warranty, you may be able to get a partial refund for it after cloud services shut down.

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GNU gettext Reaches Version 1.0 After 30 Years

Slashdot.org - Fri, 01/30/2026 - 19:22
After more than 30 years of development, GNU gettext finally "crossed the symbolic 'v1.0' milestone," according to Phoronix's Michael Larabel. "GNU gettext 1.0 brings PO file handling improvements, a new 'po-fetch' program to fetch translated PO files from a translation project's site on the Internet, new 'msgpre' and 'spit' pre-translation programs, and Ocaml and Rust programming language improvements." From the report: With this v1.0 release in 2026, the "msgpre" and "spit" programs do involve.... Large Language Models (LLMs) in the era of AI: "Two new programs, 'msgpre' and 'spit', are provided, that implement machine translation through a locally installed Large Language Model (LLM). 'msgpre' applies to an entire PO file, 'spit' to a single message." And when dealing with LLMs, added documentation warns users to look out for the licensing of the LLM in the spirit of free software. More details on the GNU gettext 1.0 changes via the NEWS file. GNU gettext 1.0 can be downloaded from GNU.org.

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