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How to install and remove software on Linux  Techloy

Trinity Desktop Environment R14.1.4 Released with Support for Ubuntu 25.04  9to5Linux

Trinity Desktop Environment R14.1.4 Released with Support for Ubuntu 25.04  9to5Linux

Widespread power outages were reported Monday in parts of Spain, Portugal and France, affecting critical infrastructure like airports and causing transportation disruptions. From a report: "The interruption was due to a problem in the European electricity grid," E-Redes, the national energy supplier of Portugal, said in a statement. In addition to Portugal, it said, "The blackout also affected regions of Spain and France, due to faults in very high voltage lines." E-Redes said that the outage was widespread across Spain, with outages in Catalonia, Andalusia, Aragon, Navarre, the Basque Country, Castile and Leon, Extremadura and Murcia. In France, the Portuguese energy supplier said, "the Basque Coast and the Burgundy region also experienced power cuts." Spain's national power company, Red Electricia, said in a post on X that it had restored some power in the north and south of the peninsula. The cause of the outages was not immediately clear. But the effects of the disruption were felt in cities across the region.

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Even PewDiePie thinks you should install Linux on your computer after saying he was "tortured by Windows"  XDA

Upgraded Open-Source EV Charging Software Stack Supports New and Legacy Apps  Electronic Design

Upgraded Open-Source EV Charging Software Stack Supports New and Legacy Apps  Electronic Design

Upgraded Open-Source EV Charging Software Stack Supports New and Legacy Apps  Electronic Design

8 ways to protect your privacy on Linux and keep your data safe  ZDNET

Avocado OS: Open-source Linux platform for embedded systems  Help Net Security

Ubuntu 25.04 Advancing The Performance Of The System76 Thelio Astra With Ampere Altra  Phoronix

Ubuntu 25.04 Advancing The Performance Of The System76 Thelio Astra With Ampere Altra  Phoronix

Sales of electric vehicles in America jumped 10.6% in the first three months of 2025 (compared to the same period in 2024), reports Bloomberg. And research provider BloombergNEF expects all of 2025 will see a 31.5% sales increase from 2024's sales in the U:S. — slightly above the global increase rate of 30%. (That's 22 million battery-powered vehicles around the world.) "EV adoption is cruising along in the U.S.," Bloomberg writes, with interest "spreading from early-adopters to mainstream consumers" tired of paying for gas and oil changes — and attracted by new products from familiar brands: Of the 63 or so fully electric cars and trucks on the U.S. market, one quarter weren't available a year ago. The product blitz includes the first EV offerings from Acura, Dodge and Jeep, second models from Mini and Porsche and two more battery-powered machines each from Cadillac and Volvo... Many of the new EVs are relatively affordable. Cox Automotive estimates the price spread between EVs broadly and internal combustion cars and trucks has shrunk to just $5,000. General Motors, meanwhile, plans to resurrect its Chevrolet Bolt later this year with a price point around $30,000...

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PoC rootkit Curing evades traditional Linux detection systems  Security Affairs

PoC rootkit Curing evades traditional Linux detection systems  Security Affairs

PoC rootkit Curing evades traditional Linux detection systems  Security Affairs

Peridio Announces Avocado OS  Business Wire

New Linux Patches Aim To Customize Out-Of-Memory Behavior Using BPF  Phoronix

Lenovo slashes Windows tax with cheaper Linux laptops  Fudzilla.com

"A new study found that a gene recently recognized as a biomarker for Alzheimer's disease is actually a cause of it," announced the University of California, San Diego, "due to its previously unknown secondary function." "Researchers at the University of California San Diego used artificial intelligence to help both unravel this mystery of Alzheimer's disease and discover a potential treatment that obstructs the gene's moonlighting role." A team led by Sheng Zhong, a professor in the university's bioengineering department, had previously discovered a potential blood biomarker for early detection of Alzheimer's disease (called PHGDH). But now they've discovered a correlation: the more protein and RNA that it produces, the more advanced the disease. And after more research they ended up with "a therapeutic candidate with demonstrated efficacy that has the potential of being further developed into clinical tests..." That correlation has since been verified in multiple cohorts from different medical centers, according to Zhong... [T]he researchers established that PHGDH is indeed a causal gene to spontaneous Alzheimer's disease. In further support of that finding, the researchers determined — with the help of AI — that PHGDH plays a previously undiscovered role: it triggers a pathway that disrupts how cells in the brain turn genes on and off. And such a disturbance can cause issues, like the development of Alzheimer's disease.... With AI, they could visualize the three-dimensional structure of the PHGDH protein. Within that structure, they discovered that the protein has a substructure... Zhong said, "It really demanded modern AI to formulate the three-dimensional structure very precisely to make this discovery." After discovering the substructure, the team then demonstrated that with it, the protein can activate two critical target genes. That throws off the delicate balance, leading to several problems and eventually the early stages of Alzheimer's disease. In other words, PHGDH has a previously unknown role, independent of its enzymatic function, that through a novel pathway leads to spontaneous Alzheimer's disease... Now that the researchers uncovered the mechanism, they wanted to figure out how to intervene and thus possibly identify a therapeutic candidate, which could help target the disease.... Given that PHGDH is such an important enzyme, there are past studies on its possible inhibitors. One small molecule, known as NCT-503, stood out to the researchers because it is not quite effective at impeding PHGDH's enzymatic activity (the production of serine), which they did not want to change. NCT-503 is also able to penetrate the blood-brain-barrier, which is a desirable characteristic. They turned to AI again for three-dimensional visualization and modeling. They found that NCT-503 can access that DNA-binding substructure of PHGDH, thanks to a binding pocket. With more testing, they saw that NCT-503 does indeed inhibit PHGDH's regulatory role. When the researchers tested NCT-503 in two mouse models of Alzheimer's disease, they saw that it significantly alleviated Alzheimer's progression. The treated mice demonstrated substantial improvement in their memory and anxiety tests... The next steps will be to optimize the compound and subject it to FDA IND-enabling studies. The research team published their results on April 23 in the journal Cell.

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